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Jastreboff and colleagues studied the obesity Phase 2 in NEJM observing mean body weight reduction reaching approximately 24 percent at the 12 mg dose tier at 48 weeks (PMID 37366315)

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Gastrointestinal side effects occur in 3045% of patients during dose escalation and require clinical oversight to adjust titration schedules and prevent discontinuation

The mega-dose biotin supplements marketed for hair growth are generally not supported by evidence