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Full structural remodeling at 4 to 6 months of bi-weekly microinfusion sessions

This may be caused by an inflammatory response in the tissue surrounding the spleen's blood vessels, which can exert pressure on the blood vessels and lead to splenic infarction [116]

The first evidence that excessive GH-levels are involved in the pathogenesis of diabetic microangiopathy came from observations in diabetic patients undergoing pituitary ablation, which resulted in improvement of diabetic retinopathy in some but not all patients [199]