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The taper follows the escalation schedule in reverse: 12mg to 8mg to 4mg to 2mg, then stop

Neuroscience (2010) 170(4):123948

It is often safe and effective over a long time when supervised by a doctor if you have diabetes or significant obesity

If you are switching from one incretin to another , allow a proper washout period first

Weight Loss While GLP-1 medications are an effective weight loss aid, results can vary based on the type of GLP-1 RA used and their dosage and duration

NICE (the National Institute for Health and Care Excellence) has not issued any guidance on retatrutide, as technology appraisals are only initiated once a medicine has received or is close to receiving regulatory approval