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& Arias, I

But there are limitations

doi: 10.1016/j.freeradbiomed.2004.02.075

doi: 10.1124/jpet.109.157685 107 ParkYJAoZKiefferTJChenHSafikhanNThompsonDMet al

The present review aims to integrate mechanistic, preclinical, and clinical evidence on ashwagandhas immunomodulatory, neuroprotective, psychiatric, sleep-regulating, and anti-inflammatory activities, with emphasis on its bioactive compounds, such as withanolides, sitoindosides, and alkaloids

Overall discontinuation rates were similar across study arms, though discontinuations related to adverse events were higher in participants with lower baseline BMIs