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Intervening before diabetes develops avoids the complications, medication burden, and lifestyle restrictions that come with a diabetes diagnosis

It could indicate inadequate caloric intake, nutritional deficiencies, dehydration, or rarely, an underlying condition unmasked by the metabolic changes

Simental-Menda, L

Pharmacological Activation of the Melanocortin System Limits Plaque Inflammation and Ameliorates Vascular Dysfunction in Atherosclerotic Mice

Diabetes Res Clin Pract 15:187195 Patzelt C, Schiltz E (1984) Conversion of proglucagon in pancreatic alpha cells: the major endproducts are glucagon and a single peptide, the major proglucagon fragment, that contains two glucagon-like sequences

& Wharton, J