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the safety and efficacy of combination therapy with phentermine and any other drug products for weight loss, including selective serotonin reuptake inhibitors (e.g., fluoxetine, sertraline, fluvoxamine, paroxetine), have not been established

Because the two pathways dont compete for the same receptors, researchers have noted this as a mechanistically distinct pairing worth studying one acting directly on adipocytes, the other acting systemically through growth hormone signaling

Petrelintide exhibits a potent balanced agonistic effect on both the AMYR and CTRwhich precludes this molecule from being included in the DACRA class [116]

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