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Myocardial ischaemia-reperfusion injury and cardioprotection in perspective

2010: FDA initially approved tesamorelin for reduction of excess abdominal fat in HIV-infected adults with lipodystrophy

2004 Mar;134(3):489-92

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The FDA prescribing information includes a boxed warning for risk of thyroid C-cell tumors and contraindication in patients with personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

| Treated with different concentrations alongside LPS stimulation [1] | | Neonatal Rat Cardiomyocytes | Protection against cardiomyocyte hypertrophy | Inhibited ET-1-induced protein synthesis ([3H]leucine incorporation)