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Very high concentrations can result in toxic effects including respiratory failure, vasodilation, hypotension, convulsions, and paralysis
Rosenstock, J
Research on B12 and Hair Loss A 2015 Journal of Drugs in Dermatology study noted acneiform eruptions (linked to hair follicle inflammation) in 8% of patients receiving high-dose B12 injections
By 1971, this practice had been discontinued, in part because it was realized that folic acid is ineffective in treating pernicious anemia, and that vitamin B-12 administration is the proper approach to treat this disease (11)
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