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[PubMed: 22631062] 94

Early mitophagy appears adaptive because it removes damaged mitochondria before they amplify oxidative and inflammatory injury, whereas later in the disease course the same pathway may become less effective, or even functionally disadvantageous, in the setting of profound ATP depletion, lysosomal dysfunction, and impaired mitochondrial replenishment

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JAMA Neurol 2013

Calculate the patients energy needs and caloric requirements based on individual factors