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doi: 10.1186/s12974-021-02231-x 11 MouYWangJWuJHeDZhangCDuanCet al

"People living with obesity need treatment options that meet them where they are and for many, a once-daily pill that can be taken with no food or water restrictions can offer them greater flexibility in how they approach their treatment," said Dr Deborah Horn, director of the Center for Obesity Medicine at McGovern Medical School at UTHealth Houston

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Domain 2 of NS5A which encompasses the C-terminal 80% of the ReED, was shown to interact with the HCV RNA dependent RNA polymerase NS5B, modulating polymerase activity 60,61,62

Results Construct of the fusion proteins Several flexible and rigid linkers were examined to select the top linker that maintains the functioning of the standard structure of the two domains of the fusion proteins (data not shown)

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