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Notably, the protonation state of bupivacaine not only influences the morphology of the liposomes but also governs the spatial distribution of drug molecules within the lipid vesicles, as illustrated in Figs

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This inhibition underlies its anti-inflammatory effects [125]

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50,51 Biological function of p53 Under physiological conditions, the expression of p53 remains low because of the interaction between p53 and MDM2, which promotes p53 proteasome degradation through its E3 ubiquitin ligase activity