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The cells were then treated with serial dilutions of S1-DOX (eight concentrations, starting from 20 M with a fourfold dilution factor)

This effect is highly similar to the ScGrx7 mutants K105A and K105Y (Figs 2 and 3)

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Further studies revealed that DPP4 acts as a binding protein for adenosine deaminase (ADA) and serves as a T cell activation marker, transmitting co-stimulatory signals upon ADA stimulation