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The reta + cag combination covers more pathways on paper, but it has no trial data of its own

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GH can act either directly on the kidneys or via circulating or paracrine-synthesized IGF-1

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To sum up, IGF-1 LR3 may boost all the anabolic effects of growth hormone and that is a powerful tool in terms of muscle mass and so on, but it does not directly raise GH levels, so could not be used for growth hormone deficiency