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Causes of High Vitamin B12 Blood Levels Increased levels of vitamin B12 can exist for a number of reasons, which can be divided roughly into the following categories: Distorted results Testing too soon after taking B12 supplements The bodys failure to utilise B12 (5) Severe diseases (4, 5) This article will take a closer look at the causes of elevated B12 blood levels, as well as considering the necessary ways to respond