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13 Lipoic acid has been usedextensively in Germany for the treatment of diabetic neuropathy

PMID: 12577686

Diabetes (2014) 63(12):426274.10.2337/db14-0163 83 BrandtILambeirAMKetelslegersJMVanderheydenMScharpeSDeMI

The chitinase-like protein YKL-40 is secreted by airway epithelial cells at base line and in response to compressive mechanical stress

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According to NICE guideline NG158 on venous thromboembolic diseases, warning signs include: Unilateral leg pain (affecting only one leg) with swelling, warmth, and redness Pain that worsens when walking or standing Tenderness along the course of the deep veins Patients experiencing these symptoms should seek urgent medical assessment, as DVT can lead to pulmonary embolism if the clot dislodges and travels to the lungs