The tumor suppressor protein p53 and the ferroptosis network
Anthony Didato, DMD Balanced Aesthetics + Wellness 90% of Serotonin Produced in the Gut Approximately 90% of the body's serotonin the neurotransmitter most associated with mood regulation is produced by enterochromaffin cells Cell (Yano et al., 2015) Gut-Brain Axis Bidirectional Communication The gut-brain axis describes bidirectional signaling between the enteric nervous system and central nervous system via the vagus nerve, immune Annals of Gastroenterology Leaky Gut (Intestinal Permeability) and Systemic Inflammation Increased intestinal permeability allows endotoxins (LPS) to enter the bloodstream, triggering systemic inflammatory cascades linked to anxiety, depression, brain fog, Frontiers in Immunology Overnight Fasting Improves Microbial Balance A 12-14 hour overnight fast improves microbial balance and insulin sensitivity
For instance, curcumin has been shown to upregulate thyroid-specific transcription factors (TTF-1, TTF-2, PAX8) and restore NIS protein expression, thereby overcoming radioiodine (RAI) resistance and enhancing RAI therapy efficacy, offering new perspectives for thyroid cancer treatment (148, 149)
By targeting NNMT and supporting NAD+ levels, it addresses cellular energy metabolism rather than manipulating appetite or stimulating the nervous system
Mutations in important arginine residues located on the p53-DNA-binding surface facilitate the loss of transcriptional activity and sequence-specific DNA binding
The mechanism of catalpol in protecting -cell functionand improving hepatic insulin resistance
