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Exenatide could promote the increase of Treg cells in mice, but inhibit the tissue infiltration of Th17 cells, suggesting that exenatide exerts immunomodulatory effects by correcting Th17/Treg imbalance (87)

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Advantages: - Once-weekly convenience for most formulas - Well-studied efficacy and safety data - More consistent absorption - Compounded versions available at lower cost Considerations: - Requires self-injection or provider administration - Needles can be a barrier for some patients Oral semaglutide (Rybelsus) is currently the only FDA-approved oral GLP-1 medication