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Targeting was confirmed by the localised expression of TdTomato from the AAV-Cre virus (Fig

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Studies have examined the dose-response relationships for MC1R-mediated melanogenesis with MT-II , comparing potency with MT-1 and native -MSH to establish the structure-activity contribution of cyclisation to MC1R agonist potency , and have characterised the kinetics of tyrosinase upregulation, melanosome distribution, and melanin transfer to keratinocytes downstream of MT-II-induced MC1R activation

doi:10.1016/j.neuropharm.2018.02.012 222

A., Cziraky, M