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The dose escalation design tested different starting doses (2 mg vs 4 mg) to evaluate tolerability
Preliminary findings indicate that TB-500 might enhance not only the viability, angiogenesis, and migration of HUVEC but could also elevate the expression of angiopoietin-2 (Ang2), TEK receptor tyrosine kinase 2 (tie2), vascular endothelial growth factor A (VEGFA), NOTCH1 intracellular domain (N1ICD), Notch receptor 3 (Notch3), NF-B, and phosphorylated (p)-p65 in these cells
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After reconstitution: Store at 28 C , protect from light, and avoid repeated temperature cycling
Maybe someday
Vasquez-Soltero, and A
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