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These agents cause sinoatrial (SA) and atrioventricular (AV) nodal depression and a decrease in myocardial contractility (nondihydropyridines)

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It should be emphasised that their role in treatment of hypertriglyceridaemia has changed significantly over the last few years, especially after the REDUCE-IT ( the Reduction of Cardiovascular Events with Icosapent EthylIntervention Trial) study was published

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