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Space radiation exposure persistently increased leptin and IGF1 in serum and activated leptin-IGF1 signaling axis in mouse intestine

Alcohol and poor diet can deplete the livers antioxidant stores

GATA4 overexpression inhibits DOX-induced autophagy and reduces cardiomyocyte death by upregulating the survival factor Bcl2 and suppressing autophagy-related genes

However, the GH/IGF-I axis in these disease states generally resets itself following the resolution of the inflammatory trigger (65)

Hardeman, E

doi: 10.3389/fonc.2026.1828367 Received 11 March 2026 Accepted 31 May 2026 Published 23 June 2026 Corrected 07 July 2026 Volume 16 - 2026 Edited by Zodwa Dlamini, Pan African Cancer Research Institute (PACRI), South Africa Reviewed by Khalida I