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Studies show the peptide increases dendritic spine density by 40-60% in treated brain regions, with formation of new functional synaptic connections confirmed by electrophysiological recordings demonstrating enhanced synaptic transmission and long-term potentiation
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These data, taken together, suggest that the NF-B pathway is activated in SGNs after peroxynitrite treatment and GPX1 can partially block the nuclear translocation of NF-B/p65 and inhibit the activation of the NF-B signaling
[DOI] [PMC free article] [PubMed] 52.Iwema T, et al
Sharma VM, Vestergaard ET, Jessen N, Kolind-Thomsen P, Nellemann B, Nielsen TS, Vendelbo MH, Mller N, Sharma R, Lee KY, Kopchick JJ, Jrgensen JOL, Puri V
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