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A long-term high-fat diet has been associated with a decrease in Mfn2 expression and an increase in Fis1 and Drp1 expression, signaling mitochondrial dysfunction [143]

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Conversely, highly active individuals with intense exercise routines may need smaller doses, as workouts naturally boost GH pulses

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however, consistent with other weight loss approaches, a substantial portion of total body weight loss is due to lean mass loss

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