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Alotaibi AA, Yilmaz M, Kadia T, DiNardo C, Borthakur G, Guerra V, Andreeff M , Konopleva M, Pemmaraju N, Jabbour E, Short N, Garcia-Manero G, Patel K, Ravandi-Kashani F, Kantarjian H, Daver N

& Romisch, K

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Al unirse a receptores especficos en el hipotlamo y el tronco enceflico, el GLP-1 estimula neuronas anorexignicas (POMC) y suprime neuronas orexignicas (NPY/AgRP), lo que se lleva a una mayor sensacin de saciedad y menor ingesta calrica

Inhibition of Na + K + 2Cl cotransporter isoform 1 accelerates temozolomide-mediated apoptosis in glioblastoma cancer cells