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"The development of human benign prostatic hyperplasia with age"

In various in-vivo and in-vitro studies, exogenous administration of IGF-1 mediated has been shown to increase glucose utilization, release acetylcholine from neurons, activate N-methyl-D-aspartate receptor (NMDA), protect the cerebromicrovascular environment, and maintenance of synaptic structure and function [36, 41,42,43,44,45]

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These findings suggest that future therapeutic strategies may focus on enhancing the nerve-bone communication pathway rather than administering CGRP directly

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Guidance for industry and FDA staff: Technical considerations for pen, jet, and related injectors intended for use with drugs and biological products