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Longitudinal studies with DEXA scans and serum marker monitoring will be crucial to confirm these associations and elucidate underlying mechanisms.

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The selectivity data, animal pharmacology, and human GI trial data collectively represent a meaningful evidence base

112 However, in recent years, the FDA has introduced the patient-focused drug development initiative, where patient-reported outcomes such as improvements in quality of life and healthy life years in MASH patients following treatment can serve as trial endpoints, potentially influencing final approval based on these data

JAMA 289, 16811690