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Impaired TLR9 responses in B cells from patients with systemic lupus erythematosus

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To assess the effects of BHBA on intracellular Ca 2+ levels, hippocampal neurons were loaded with the calcium-sensitive fluorescence indicator Fluo-4AM, and the changes in fluorescence intensity were measured in all cell bodies of neurons (Figure 3A)

Acrylamide, a Maillard reaction contaminant abundant in fried foods, down-regulates endothelial tight-junction proteins, weakening BBB integrity and permitting infiltration of inflammatory mediators, leading to neuroinflammation (74)

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