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A study by the same group in the longitudinal DATATOP cohort (deprenyl and tocopherol antioxidative therapy of Parkinsonism) which included individuals with early PD in a placebo-controlled clinical trial reported increased CSF pS129 and pS129/total -synuclein ratio over 2 years of disease progression (Stewart et al., 2015)

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While no significant dangers have been identified, ongoing supervision is recommended to monitor for any potential side effects

Gassei K, Orwig KE

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