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Intermediate-affinity LFA1 binds -actinin-1 to control migration at the leading edge of the T cell
As such, niclosamide can inhibit virus replication as demonstrated in Vero 6 cells at only 1M (10) and has also been shown to have similar anti-replicative efficacy in cultured Calu-3 lung cells, at 2M (34)
Laboratory investigations have examined its interactions with growth factor signaling, nitric oxide pathways, and fibroblast activity in tissue culture and preclinical contexts
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Merck KGaA, Darmstadt, Germany), MS settings of the screening method used in 20202023 were switched to high-mass detection (m/z 7003,000) and the ESI-L LCMS Tuning Solution (Agilent Technologies) was used for calibration, whereas, in the screening method used in 2024 the data acquisition range was changed to m/z 1003,000, and a sodium iodide solution was used for MS calibration