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Their activity depends on maintaining an intact molecular structure, which can be affected by time and handling

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Abstract Background Tirzepatide, a once-weekly glucose-dependent insulinotropic polypeptide/ glucagon-like peptide-1 receptor agonist, is approved in the United States, Europe and Japan for the treatment of type 2 diabetes

Individual response varies significantly based on genetic factors and surgical recovery status

Instructing the patient to administer the evening NPH insulin dose at bedtime rather than before dinner helps prevent insulin waning and ensures better glycemic control upon waking