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This imbalance leads to the infiltration of M1 macrophages, forming CD11c+ crown-like structures (CLS) around dead cells in WAT, resulting in the accumulation of high amounts of lipids within macrophages and promoting inflammation [99, 101]

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These flavonoids can also induce glial cell secretion of nerve growth factor to prevent the degradation of dopaminergic neurons in the substantia nigra (Jaeger et al., 2018)