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Stacking two GLP-1 agonists amplifies gastrointestinal effects: severe nausea, vomiting, constipation, and appetite loss without additional weight loss

This is because of dosing rules with oral GLP-1 drugs (e.g., empty stomach, 30 mins before food and other medications)

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It might not always taste the best

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An interesting observation that deserves further exploration is the inherent ability of intra-portal insulin to regulate hepatic GH sensitivity that remains preserved despite prevailing changes in peripheral insulin resistance