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We next assayed cAMP-dependent protein kinase (PKA) (27, 35), ERK (36), and eNOS (37) activations as putative downstream targets of GLP-1(2836)induced cAMP and/or molecules known to be involved in GLP-1mediated cytoprotection (21)

Significantly increased serum levels of GSH were reported in MASLD/MASH patients as compared to healthy volunteers (Koruk et al

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Furthermore, expression of SLC7A11, a GSTO1 and C1-27 target gene, was increased in C1-27 -treated tumours indicating target engagement (Fig