Drugs 20 (8), 528
General Daily Dosage: Protocols suggest extremely low doses, ranging from 20 mcg to 80 mcg per day
Symptoms of overmethylation can include: [23] Restless legs/pacing Hyperactivity High pain tolerance Histamine intolerance Sleep disorders Panic disorders Paranoia Insomnia Low libido ADHD Low motivation Depression Anxiety High levels of neurotransmitters (dopamine, norepinephrine, and serotonin) A high copper to zinc ratio Generally, undermethylation will result in symptoms more akin to depression and sluggishness, while overmethylation is usually linked to symptoms like hyperactivity and anxiety
[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Chabory E., Damon C., Lenoir A., Kauselmann G., Kern H., Zevnik B., Garrel C., Saez F., Cadet R., Henry-Berger J., et al
Vitamin B6 supports neurotransmitter production, including serotonin and dopamine
1- Autologous chondrocyte implantation: Failure rates reach 18.2% in complex cases and up to 87.5% in salvage cases