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In large clinical trials, participants with overweight or obesity who took tirzepatide lost, on average, 15% to 22% of their body weight over approximately 72 weeksa result that surpasses many other current weight loss medications

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Most of these symptoms are observed at the expense of increased oxidative stress (Wei et al

The medication also produced a mean 9.4% weight loss and improvements in blood pressure (3.3 mm Hg systolic), inflammatory markers (37.8% high-sensitivity CRP), and lipid profilesall achieved on top of existing treatments

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