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Potential risks include elevated heart rate and blood pressure from phentermine combined with unpredictable GI effects from tirzepatide, including nausea, vomiting, and diarrhea that could worsen

doi:10.1007/s11894-021-00827-0

Studies show that people taking semaglutide can lose a significant amount of weight, making it a promising solution for those struggling with obesity

This is thought to be related to GLP-1s effects on the brains dopamine reward pathway, says Nitya Kumar, MD, an endocrinologist and an assistant professor of medicine at the Duke University School of Medicine in Durham, North Carolina