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When PGH synthase is activated, the peroxidase function of the enzyme generates oxygen radicals that could interact with polyunsaturated fatty acids in the placenta to form lipid peroxides

RNA replication takes place via the viral RNA-dependent RNA polymerase NS5B, which produces a negative strand RNA intermediate

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If an RCE is submitted after the three-year term, the B delay is calculated up to the day the RCE is filed