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The misplaced endometrial tissue triggers immune system activation, releasing pro-inflammatory cytokines including interleukin-1 beta (IL-1), tumor necrosis factor-alpha (TNF-), and interleukin-6 (IL-6)

However, the authors note that this prior research on its effects on lipid profiles has yielded inconsistent results

A mechanism of action phase 1 study showed that the glycemic efficacy of tirzepatide in T2DM results from concurrent improvements in key components of diabetes pathophysiology, including -cell function, insulin sensitivity, and glucagon secretion (135)