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They are approved for managing type 2 diabetes and weight-related conditions, and any mental health benefits are likely secondary to metabolic improvements rather than direct anxiolytic effects

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However, it is typically administered to patients with a Body Mass Index (BMI) of 30 or higher, or a BMI of 27 or higher who have at least one weight-related health condition, such as hypertension or high cholesterol

Scirica BM, Braunwald E, Raz I, Cavender MA, Morrow DA, Jarolim P, Udell JA, Mosenzon O, Im K, Umez-Eronini AA, Pollack PS, Hirshberg B, Frederich R, Lewis BS, McGuire DK, Davidson J, Steg PG, Bhatt DL, SAVOR-TIMI 53 Steering Committee and Investigators

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Compared with the rotenone group, the sulforaphane + rotenone group demonstrated increased protein expression of HO-1, 1.4-fold higher in the cerebral cortex and 1.6-fold higher in the striatum, respectively (Fig