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Pregnancy or medical conditions sometimes require stopping semaglutide

The additional carboncarbon bond in -amino acids increases the flexibility of the peptide bond, which can be a disadvantage when designing peptide drugs that need to bind to a specific protein site

Debnam JM, Vu T, Sun J, Wei W, Krishnamurthy S, Zafereo ME , Weitzman SP, Garg N, Ahmed S

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Thus, there is a need to rethink the exclusion criteria currently being employed in AD/ADRD clinical trials to ensure that researchers are not inadvertently excluding individuals who could both benefit from and contribute to the success of any given trial