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98 Although located in the sinoatrial node, GLP-1 RAs influence the cardiovascular system through several other mechanisms, including the use of myocardial glucose, improvement of left ventricular function, myocardial ischaemic protection, increased heart rate, vasodilation, anti-atherosclerotic effects, and blood pressure reduction

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All these steps are the researchers best attempt to mimic a randomized control trial and make any results more believable as real effects of the drugs

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It has been suggested that the endocrine system could play a role, especially the renin-angiotensin-aldosterone system (RAAS)