By incorporating RWE into clinical trials, researchers can get a more comprehensive understanding of patient experiences and outcomes, which can help to improve trial design and recruitment
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The main difference is the route of administration
Specifically, changing the Val229 residue to alanine, selected in this study for further investigation, was predicted to trigger a change in the cavity and a buried exposure switch at the inactive receptor, thereby potentially modifying the interactions between itself and other pocket residues with cholesterol