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Quantitative analysis of IHC human post-mortem brain sections Scanned human brain sections were analysed by ImageScope where the image was split into four separate colour channels (blue: negative, yellow: weakly positive, orange: moderately positive and red: strongly positive pixels)

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Mechanism of Action Pancreas: Increases glucose-dependent insulin secretion, decreases glucagon Brain: Enhances satiety Stomach: Slows gastric emptying Main Indications Type 2 diabetes mellitus Obesity/weight management Cardiovascular risk reduction Common Drugs Exenatide Liraglutide Semaglutide Dulaglutide Tirzepatide (dual GIP/GLP-1 agonist) Key Benefits Significant weight loss Low hypoglycemia risk Cardiovascular protection Major Side Effects Nausea/vomiting (most common) Pancreatitis (rare) Thyroid C-cell tumors (boxed warning) Contraindications Multiple Endocrine Neoplasia type 2 (MEN2) Personal/family history of medullary thyroid carcinoma #Pharmaceuticals #GLP1 #Diabetes #Obesity #Healthcare #Biotech #ClinicalResearch #Endocrinology #MedicalAffairs GLP-1 Analogues: Mechanism, Indications, and Side Effects GLP-1 Analogues : Definition Synthetic versions of the natural hormone GLP-1 (glucagon-like peptide-1) that are resistant to DPP-4 breakdown, providing longer-lasting effects

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One case report showed a 23-year-old with PWS achieving 10-pound weight loss and improved appetite control within 8 weeks