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The 28-Day Rule Once reconstituted with bacteriostatic water, semaglutide is stable for up to 28 days refrigerated the same window as most other peptides

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Dose adjustments should aim for the lowest appropriate dose to limit side effects and improve adherence

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The cardiovascular outcomes trial (SURPASS-CORE and SURPASS-PLUS) extended follow-up beyond two years, with no new safety signals emerging