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Reduced T3 levels of steroidogenic acute regulatory protein (StAR) mRNA, protein in Leydig cells, and testosterone production occur ( Cellular response against inflammation and infertility Inflammation is a natural defense against foreign invaders that causes cellular injury and subsequently results in the restoration of tissue function ( Previous literature indicate a relationship between oxidative stress and inflammation

Furthermore, its exposure could damage Leydig cells, seminiferous tubules, and testicular degeneration (66)

doi: 10.1074/jbc.M111.314062 28 YangWLiangZWenCJiangXWangL

One study found people with obesity who had higher levels of glutathione lost more weight when they followed a healthy eating plan for 6 months

Environmental pollution is a major contributor to oxidative stress in sperm

The gene encoding this transporter is identified as SLC12A1 which is located on chromosome 15q21.1 and is composed of 29 exons that generate two alternatively spliced mRNAs