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Figure 5 In some systematic reviews and meta-analyses, the publication dates of the included studies were relatively early and the intervention dosages maybe unreasonable

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What constitutes a suitable dosage will depend on the condition you wish to address, for example for blood sugar effects a dose of 500mg, taken three times daily after meals, has been reported to work well. It should be noted, that there is more for us to learn with regards berberines clinical effects and more high-quality studies needed

Eccentric loading, structured physiotherapy, activity modification, and where appropriate platelet-rich plasma

Meanwhile, for weekly formulations, clinicians may advise skipping a dose one week prior