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We retrospectively identified all deliveries at Hirosaki University Hospital between January 2008 and December 2019 using electronic medical records

A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells

The absence of elevated insulin allows IGF-1 to bind receptors more effectively

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2012;6(7):e1729

Cartilage faces even greater obstacles given avascular nature (no blood vessels penetrating tissue), low cell density (chondrocytes sparse within extensive extracellular matrix), minimal metabolic activity (slow turnover and repair), and mechanical loading challenges (constant stress impeding healing)