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The calculus that drives at-risk launches involves comparing the expected value of early market entry against the probability-weighted cost of an adverse judgment

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In addition, the distinction between physiological and pharmacological doses of vitamin C, determined by the route of absorption as well as by the pro-oxidant and antioxidant effect of different doses of vitamin C dependent of the redox balance of the individual, allows us to understand why some previous studies have failed to demonstrate the health benefits of vitamin C

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