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Instead, research points to activity across multiple interconnected systems, including modulation of the nitric oxide (NO) system, upregulation of growth factor expression (notably VEGF, EGF, and FGF pathways), promotion of angiogenesis, and activation of the FAK-paxillin signalling pathway involved in cell migration and tissue organisation

When our mitochondrial energy drops, the cells sensitivity to excitotoxicity is greatly increased so that exposure to even normally occurring amounts of neurotransmitters, such as exposure to glutamate, can create an excitotoxic effect

doi: 10.1016/j.nano.2012.06.002

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