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Instead, we deliberately paused to allow the regulatory framework to stabilize and to ensure that our future assessment is performed using the most up-to-date requirements and best practices, while continuing to seek a meaningful balance between Ascendis Pharmas strategic priorities and focus areas and the evolving reporting requirements

The fasted state keeps insulin levels low, which allows the peptide to more effectively target fat cells for breakdown

The liver then oxidizes this TMA into Trimethylamine N-oxide (TMAO), a metabolite strongly associated with an increased long-term risk of atherosclerosis and cardiovascular disease